Despite the common expression of death receptors, many types of cancer including gliomas are resistant to the death receptor ligand (TRAIL). Melatonin antitumoral actions have been extensively described, including oncostatic properties on several tumor types and
improvement of chemotherapeutic regimens. Here, we found that melatonin effectively increase cell sensitivity to TRAIL-induced cell apoptosis in A172 and U87 human glioma cells. The effect seems to be related to a modulation of PKC activity which in turns decreases Akt activation leading to an increase in death receptor 5 (DR5) levels and a decrease Cheap Hollister Canada
in the antiapoptotic proteins survivin and bcl-2 levels.
73 fatigued and 45 unfatigued members of the British Army completed a 16-item adjective checklist, derived from the Nowlis Mood Adjective Checklist. The Cheap Hollister Sweaters
items had been selected to provide a subjective measure of fatigue. Although the scores could differentiate between the two groups, they did not correlate with an objective measure of fatigue. Significant relationships were found between EPQ-scores and the checklist scores, suggesting that extraverts denied feeling fatigued while neurotics exaggerated their fatigue. Susceptibility to effects of social desirability, as measured by the lie-scale, was also found to decrease self-rated fatigue.